Skip to product information
1 of 5

DAO enzyme & Vitamin C

Aperitif Diamine Oxidase 60 Capsule Refill Pouch

Aperitif Diamine Oxidase 60 Capsule Refill Pouch

Regular price £75.00
Regular price Sale price £75.00
Sale Sold out
UK shipping included
View full details
Free from 12 allergens
Gluten, lactose and soy and 9 others not included. Full list below.
48,000 HDUs
Market leading histamine degrading units per capsule. Third party tested.
Free shipping, always
Checkout with tracked Royal Mail shipping, without any hidden surprises.
British Owned
Independent brand dedicated to the discovery and management of histamine intolerance.
Made in the EU
All ingredients sourced and manufactured to strict European quality standards.
Refillable, recyclable
Reuse your 30 capsule glass jar with the 60 capsule refill pouch.

The routine

How Aperitif works

You're new pre-meal routine. Take moments before a high-histamine meal. The delayed-release capsule opens in your gut, where the DAO enzyme goes to work.

01

Take up to three capsules

Take 15–20 minutes before high histamine meals. Whole, don't open the capsule.

02

Reaches the gut

The delayed-release capsule shields the DAO through your stomach, opening in your digestive system at the most effective ph level.

03

DAO breaks histamine down

Supplements your body's own DAO enzyme to metabolise dietary histamine before it enters your bloodstream.

04

Enjoy the meal

Any histamine found in the food and drink is eaten up by Aperitif, keeping your histamine bucket from overflowing.

Every capsule

Two active ingredients

Deliberately pure formula. The DAO enzyme is how Aperitif breaks down histamine. The vitamin C is there because it supports the DAO's activity and bioavailability. Nothing else needed.

Enzyme

Diamine Oxidase (DAO)

4.2mg · per capsule

DAO is the enzyme your body uses to break down dietary histamine in the gut. Aperitif is a supplement for the body's naturally produced DAO enzymes, which may be impacted for a number of reasons, including gut health, hormones and genetics.

Cofactor

Vitamin C

12mg · per capsule

Enhances the bioavailability of the DAO and is a natural antihistamine in its own right, helping to stabilise mast cells. There for enzyme performance, not padding.

Full ingredients list

Every non-active ingredient has a function, chosen for capsule integrity and delayed-release performance.

Diamine Oxidase (DAO) 4.2mg
Vitamin C (ascorbic acid) 12mg
Microcrystalline cellulose Bulking agent
Hypromellose (capsule shell) Vegetarian-friendly shell
Magnesium stearate Flow agent
Gellan gum Delayed-release coating
Allergen information

Contains porcine-derived ingredients. Not suitable for vegetarians, vegans, or halal/kosher diets.

Free from

  • Gluten
  • Lactose / Dairy
  • Soy
  • Tree Nuts
  • Peanuts
  • Egg
  • Shellfish
  • Fish
  • Sesame
  • Sulphites
  • Gelatin
  • Artificial additives
  • 5 stars: 47 (92%)
  • 4 stars: 4 (8%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
Some of the reviews shown are from related products the merchant grouped with this one.
M
MRS R.
Very good product - helps a lot with MCAS food issues

Very good product - helps a lot with MCAS food issues. Ordering is simple and the processing and delivery is prompt

E
Elizabeth M.
Can’t recommend this enough

Can’t recommend this enough, my practitioner recommended I try taking it after an elimination diet. I still can’t eat some things but I can eat so much more than I could before!

N
Nicholas R.

I’ve been trying for a while to work out my reactions, and these really seem to help!

O
Oliver M.
I used to use a vegan DAO but they didn't seem to do anything

I used to use a vegan DAO but they didn't seem to do anything, since I found tolerance it's really seemed to make a difference

C
Chris H.
A great help!

I’ve been on the enzymes for several months now and they help me immensely! I’m going on holiday and will take them with me to use frequently. You just never know if some of the foods might have more histamine in them than our bodies can cope with. It’d be great not to need them but when I can see and I can feel a marked difference from taking them, they’re a bit of a lifeline. Andrew, whom I’ve emailed with questions, from time to time, has been extremely kind and helpful. Thank you!

H
Hannah
Definitely Recommend!

I’d highly recommend tolerance. After suspecting a histamine intolerance and doing an elimination diet - tolerance has allowed me to reintroduce some higher histamine foods that previously would cause me issues.

I also have anaphylactic food allergies to legumes so finding a product that doesn’t have pea in it was huge for me. The clear and quality ingredients were a dealbreaker for me and the customer service has been excellent!

If you’re dealing with a histamine intolerance I would definitely recommend this product to allow you to enjoy some good foods again! ☺️

E
E.W.
Good product

I started taking Tolerance about 6 weeks ago and it’s making a difference. DAO is a good supplement/enzymes and they make it a little easier to understand. I’m sick of histamine intolerance but hopefully it will go away 😅

D
Diane M.
Great Product

It makes such a difference to my life to be able to take a capsule which allows me to eat some of the higher histamine foods. It makes eating out, travel and visiting friends so much easier and more enjoyable.
A great company to deal with, a very responsive team and a real person to communicate with. Thank you for all you are doing.

N
Nissa
recommend as supplement

I've been using tolerance for a while and feel they work well for me although don't solve the problem.
my client on the other hand has had great help with taking tolerance dao with food.
I feel they are good quality and trust the brand. good value when you subscribe.
I take mainly with high histamine foods .
but do feel not the only support required for those with histamine intolerance as can be quite complex as in my case.

Z
Zuzana S.
This does seem to help!

With this enzyme I find I can eat foods I wasn’t able to before. It’s good protection against these, just in case.

A
Alex L.
One of the better supplements I’ve tried

Great company! Had Dao from Amazon. Found Tolerance and much better. Will likely stick around!

E
Elizabeth L.M.
DAO Saviours!! x

I have been taking tolerance DAO tablets for nearly a year now and after trying other brands which don’t work for me, I can honestly say this little tablet has been a game changer! 😃X Adapting to a histamine intolerance lifestyle is very challenging but this DAO has given me more confidence to add more higher histamine foods to my diet at home …. And Allelujhia!! I can also go out to restaurants again without feeling too overwhelmed thinking about the consequences ! The customer service at Get tolerance is also 2nd to none !…Please don’t ever stop making this little gem !! A massive thank you to the lovely and brilliant dietitian Nicola from the “Dietary Edit” for recommending this brand. If you need help navigating histamine intolerance I wouldn’t hesitate to recommend Nicola and also this company .. both are amazing !!🤩 Xxx

R
Rachael H.
Love it

I was sceptical as I’ve tried vegan dao before and that didn’t work for me, but this has worked wonders! So glad I discovered this!

M
Michelle G.
Very helpful

I found out that I had histamine intolerance recently, and a dietitian recommended I tried these. They’ve definitely helped me be able to digest foods with more histamine in them. It’s made having a glass of wine so much more enjoyable too.

W
Wendy S.
The best!

Brilliant product, excellent customer service and helpful information.

H
Holly B.
Great product!

Tolerance has helped me to manage my histamine intolerance, it’s cleared my skin, helped my gut health & massively reduced my chronic pelvic pain! I feel like I’m finally getting somewhere with my health.

R
Rob
Game changer

I've been using Tolerance in combination with anti-histamines and have found it to make a real difference! Basically all symptoms have been eliminated. My issues were primarily alcohol related. Love what the team are building here.

E
Emily B.
Surprisingly effective

These have helped a lot. A friend told me about DAO after always feeling a little funny after eating out and having red wine. These seem to be helping quite a lot with it all as I couldn’t quite put my finger on. Relief!!

S
Scott R.
100% Recommend!

I’ve been using this product for quite a few months now, and it’s now an essential part of my healthcare. I can tolerate so many foods I couldn’t before, and my environmental allergies have also improved, some have completely gone. All of my body’s systems are generally just working better than before. I wish I’d found this sooner!

V
Vik
The most effective treatment

After 4 decades living with eczema, tolerance has been the most effective treatment I've ever used. Has been life-changing.

R
Robyn S.
It’s working

Dear Team.

My husband has fibromyalgia and therefore sensitivities to most supplements I try to find that might be of help. I keep trying and he’s very patient with me. However his sensitivities have meant stopping most of them after 4 weeks. Tolerance histamine has we believe helped lift some of the brain fog, he’s had lots of things going on which has increased his anxiety so it’s difficult to be precise in his evaluation. But it seems to have had a really positive effect on his ability to think clearly, with no adverse effects at all. Thank you

C
Chris H.
They do help!

These capsules have really helped! I’ve been on them over a month and many of the congestion, nasal, gluey symptoms that would wake me in the night have decreased massively. I’ve been taking 2-3 a day because I’ve not yet fully started the 1st stage of the elimination plan. I’m hoping I can cut down once I fully commit to that. The capsules are easy to take. The only downside for me is the cost but I know these are the best as recommended by my dietitian. Maybe in years to come the prices may reduce. Overall, with the product, and customer care, I am extremely impressed!

L
Louisa M.
A life line!

Discovering Intolerance was a game-changer. I'd been hit by menopause and was eating such a limited diet, and now I can eat normally - it's literally changed my life. I'm really grateful to the founders, and I've been impressed by everything from their service to their packaging. Thanks for making such a difference.

J
J.T.
Early days for me but trying for long Covid

As I say early to chart progress but hopeful

V
Vik
Life-changing

I have suffered from eczema for over 45 years. These capsules have given me more relief than any topical steroid ever has, improving my sleep and quality of life immensely.

E
Eleanor D.
A fantastic help if you have histamine intolerance

This has helped me broaden my diet - can now occasionally eat beans, pulses and cheese thanks to this., without fear of all the symptoms I would otherwise get. There was a problem with my order, fantastic customer service that really stands out. . I order on subscription now, helps save a little money. Worth every penny.

A
Alice R.
The best DAO I've tried

I've tried probably all the different dao products available over the past year and can honestly say that this is the best one for me. Thank you so much!

A
Anonymous
Aperitif refill pouch

Aperitif capsules are small and easy to take. I have found they are most effective for me if taken on a regular basis rather than ad hoc. For me, this means taking one on waking and two before my evening meal, having set my phone alarm to remind me to take them. I also carry a small pot of capsules in my bag to use if eating out. I now eat a pretty normal diet and if I do get symptoms, they are less intense and do not last as long as previously. Generally, I feel that my body is much less reactive than prior to starting Aperitif. Thanks also to Andrew for answering my many questions.

A
Ally K.
Excellent customer service

Customer service was excellent - quick, helpful and very responsive. Although I didn’t try the product in the end (as it’s porcine based) so can’t comment on that - I would absolutely recommend the company!

N
Nissa
Great product

I have been using this DAO for a couple of months. The product and company are trustworthy and although I can't really tell if it's helping with my histamine intolerance, I know my body requires Dao as I don't genetically make it.
I am intending to try it more regularly now with hope it helps. I do sense my reactions are not as strong with these so that's a plus

Jar or pouch?

Same formula, same dose, same delayed-release capsule.

Start here

Aperitif Jar

  • Ideal for first-time Aperitif customers
  • 30 capsules in a reusable glass jar
  • 48,000 HDUs per capsule
  • Take 15 to 20 minutes before high-histamine meals
  • Keep the jar and pour your refill pouch straight in
For your refill

Aperitif Refill Pouch

  • Best for your second purchase onwards
  • 60 capsules, twice the count
  • 48,000 HDUs per capsule
  • Slim, letterbox-friendly pouch
  • Pours directly into your existing jar

FAQs

Product

5 questions
How many capsules are in a jar and pouch?

A glass jar contains 30 enteric-coated capsules. A refill pouch contains 60 capsules.

What are the ingredients in Aperitif?

Aperitif is made from the highest quality ingredients, in accordance with strict EU manufacturing standards. The formulation strives for the highest level of bioavailability and absorption.

Where are the ingredients sourced?

All ingredients in Aperitif, including the gut resistant capsules, are sourced from the EU.

What about the production standards?

Aperitif is produced in accordance with European standards. The production is IFS GMP-certified (International Featured Standards for Good Manufacturing Practices).

How can I speak with a nutritional histamine expert?

The first step is to take our questionnaire. You can then find Tolerance's trusted UK nutritional histamine experts on the About Us page. You also have access to Tolerance x Lifecode Gx histamine genetic tests.

Usage

2 questions
Are there any side effects?

The ingredients in our supplement are generally considered safe when taken as per the directions found on the jar or refill pouch.

What is histamine intolerance?

Histamine intolerance occurs when your body can't break down histamine properly. A root cause of histamine intolerance is a deficiency or inefficiency of the enzymes that break down histamine, particularly diamine oxidase (DAO).

Say yes, get Tolerance.

One capsule before the meals you couldn't before. Subscribe & save, cancel any time.

View Products