What is Aperitif DAO enzyme supplement?

Aperitif is a premium diamine oxidase (DAO) enzyme supplement designed to support the breakdown of dietary histamine and help manage symptoms associated with histamine intolerance and DAO deficiency. Each capsule contains DAO and vitamin C to enhance bioavailability and effectiveness. :contentReference[oaicite:0]{index=0}

How does Aperitif help with histamine intolerance?

Aperitif provides exogenous DAO enzymes which help degrade histamine from foods in the gut before it enters the bloodstream, potentially reducing symptoms of histamine intolerance such as headaches, digestive discomfort, flushing, and congestion. :contentReference[oaicite:1]{index=1}

When should I take an Aperitif capsule?

Take one Aperitif capsule 15–20 minutes before consuming foods or drinks that are high in histamine to give the enzyme time to be active in your digestive tract as the meal arrives. :contentReference[oaicite:2]{index=2}

How many capsules of Aperitif are in a jar?

Aperitif comes in a glass jar containing 30 enteric-coated capsules designed to release their active ingredients in the intestine. :contentReference[oaicite:3]{index=3}

What are the key ingredients in Aperitif?

The main active ingredients in Aperitif are diamine oxidase (DAO) enzyme derived from porcine kidney extract and vitamin C, encapsulated in a delayed-release capsule for optimal histamine breakdown. Other non-active ingredients support enzyme stability. :contentReference[oaicite:4]{index=4}

Can I open or break open an Aperitif capsule?

No — the delayed-release capsule is designed to resist stomach acid and ensure the active DAO enzyme is released in the intestinal tract where it can work effectively. Opening the capsule can reduce its effectiveness. :contentReference[oaicite:5]{index=5}

Are there any side effects of taking Aperitif?

Ingredients in Aperitif are generally considered safe when taken as directed. The DAO enzyme works in the digestive system and is not absorbed. However, consult with a healthcare professional before starting any new supplement, especially if you have pre-existing conditions or are taking medication. Stop use and seek advice if you experience any adverse reactions. :contentReference[oaicite:7]{index=7}

How many capsules of Aperitif can I take in a day?

The recommended maximum daily intake of Aperitif is three capsules per day, taken before meals or drinks that may be high in histamine. :contentReference[oaicite:8]{index=8}

Where are Aperitif ingredients sourced and produced?

All ingredients in Aperitif, including the DAO enzyme and delayed-release capsules, are sourced within the EU and manufactured according to strict European quality standards with IFS GMP and HACCP certification. :contentReference[oaicite:9]{index=9}

Can Aperitif help me enjoy high-histamine foods more comfortably?

Aperitif may make eating high-histamine foods more comfortable for people with histamine intolerance by boosting the breakdown of histamine during digestion, but individual responses vary and symptom relief is not guaranteed for everyone. :contentReference[oaicite:10]{index=10}

How do DAO supplements like Aperitif work compared to dietary changes?

DAO supplements like Aperitif provide temporary enzymatic support to break down histamine from food, whereas dietary changes (such as a low-histamine diet) aim to reduce the amount of histamine you consume overall. Many people use both strategies to manage histamine intolerance symptoms. :contentReference[oaicite:11]{index=11}

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DAO enzyme & Vitamin C

Aperitif Diamine Oxidase 30 Capsule Jar

£40.00

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UK shipping included

Aperitif Jar From £36 30 capsules Refill Pouch From £66 60 capsules

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Free from 12 allergens

Gluten, lactose and soy and 9 others not included. Full list below.

48,000 HDUs

Market leading histamine degrading units per capsule. Third party tested.

Free shipping, always

Checkout with tracked Royal Mail shipping, without any hidden surprises.

British Owned

Independent brand dedicated to the discovery and management of histamine intolerance.

Made in the EU

All ingredients sourced and manufactured to strict European quality standards.

Refillable, recyclable

Reuse your 30 capsule glass jar with the 60 capsule Aperitif Refill Pouch.

The routine

How Aperitif works

You're new pre-meal routine. Take moments before a high-histamine meal. The delayed-release capsule opens in your gut, where the DAO enzyme goes to work.

01

Take up to three capsules

Take 15–20 minutes before high histamine meals. Whole, don't open the capsule.

02

Reaches the gut

The delayed-release capsule shields the DAO through your stomach, opening in your digestive system at the most effective ph level.

03

DAO breaks histamine down

Supplements your body's own DAO enzyme to metabolise dietary histamine before it enters your bloodstream.

04

Enjoy the meal

Any histamine found in the food and drink is eaten up by Aperitif, keeping your histamine bucket from overflowing.

Every capsule

Two active ingredients

Deliberately pure formula. The DAO enzyme is how Aperitif breaks down histamine. The vitamin C is there because it supports DAO's activity and bioavailability. Nothing else needed.

Enzyme

Diamine Oxidase (DAO)

4.2mg · per capsule

DAO is the enzyme your body uses to break down dietary histamine in the gut. Aperitif is a supplement for the body's naturally produced DAO enzymes, which may be impacted for a number of reasons, including gut health, hormones and genetics.

Cofactor

Vitamin C

12mg · per capsule

Enhances the bioavailability of DAO and is a natural antihistamine in its own right, helping to stabilise mast cells. There for enzyme performance, not padding.

Full ingredients list

Every non-active ingredient has a function, chosen for capsule integrity and delayed-release performance.

Diamine Oxidase (DAO) 4.2mg

Vitamin C (ascorbic acid) 12mg

Microcrystalline cellulose Bulking agent

Hypromellose (capsule shell) Vegetarian-friendly shell

Magnesium stearate Flow agent

Gellan gum Delayed-release coating

Allergen information

Contains porcine-derived ingredients. Not suitable for vegetarians, vegans, or halal/kosher diets.

Free from

Gluten
Lactose / Dairy
Soy
Tree Nuts
Peanuts
Egg
Shellfish
Fish
Sesame
Sulphites
Gelatin (in shell)
Artificial additives

Good product

I started taking Tolerance about 6 weeks ago and it’s making a difference. DAO is a good supplement/enzymes and they make it a little easier to understand. I’m sick of histamine intolerance but hopefully it will go away 😅

Great Product

It makes such a difference to my life to be able to take a capsule which allows me to eat some of the higher histamine foods. It makes eating out, travel and visiting friends so much easier and more enjoyable.
A great company to deal with, a very responsive team and a real person to communicate with. Thank you for all you are doing.

recommend as supplement

I've been using tolerance for a while and feel they work well for me although don't solve the problem.
my client on the other hand has had great help with taking tolerance dao with food.
I feel they are good quality and trust the brand. good value when you subscribe.
I take mainly with high histamine foods .
but do feel not the only support required for those with histamine intolerance as can be quite complex as in my case.

This does seem to help!

With this enzyme I find I can eat foods I wasn’t able to before. It’s good protection against these, just in case.

One of the better supplements I’ve tried

Great company! Had Dao from Amazon. Found Tolerance and much better. Will likely stick around!

DAO Saviours!! x

I have been taking tolerance DAO tablets for nearly a year now and after trying other brands which don’t work for me, I can honestly say this little tablet has been a game changer! 😃X Adapting to a histamine intolerance lifestyle is very challenging but this DAO has given me more confidence to add more higher histamine foods to my diet at home …. And Allelujhia!! I can also go out to restaurants again without feeling too overwhelmed thinking about the consequences ! The customer service at Get tolerance is also 2nd to none !…Please don’t ever stop making this little gem !! A massive thank you to the lovely and brilliant dietitian Nicola from the “Dietary Edit” for recommending this brand. If you need help navigating histamine intolerance I wouldn’t hesitate to recommend Nicola and also this company .. both are amazing !!🤩 Xxx

Love it

I was sceptical as I’ve tried vegan dao before and that didn’t work for me, but this has worked wonders! So glad I discovered this!

Very helpful

I found out that I had histamine intolerance recently, and a dietitian recommended I tried these. They’ve definitely helped me be able to digest foods with more histamine in them. It’s made having a glass of wine so much more enjoyable too.

The best!

Brilliant product, excellent customer service and helpful information.

Great product!

Tolerance has helped me to manage my histamine intolerance, it’s cleared my skin, helped my gut health & massively reduced my chronic pelvic pain! I feel like I’m finally getting somewhere with my health.

The science behind Aperitif

All articles →

Histamine Hub

What is Diamine Oxidase (DAO)?

The enzyme behind histamine intolerance, and why supplementing it can make a difference.

Histamine Hub

Understanding your histamine bucket

Why clearance capacity is more useful than any single trigger food, and what to do when the bucket fills.

Getting the Most from Your DAO Enzyme Supplement: A Practical Guide

Histamine Hub

Getting the most from your DAO supplement

A practical guide to timing, dosage and when Aperitif is most useful.

Jar or pouch?

Same formula, same dose, same delayed-release capsule.

Start here

Aperitif Jar

Ideal for first-time Aperitif customers
30 capsules in a reusable glass jar
48,000 HDUs per capsule
Take 15 to 20 minutes before high-histamine meals
Keep the jar and pour your refill pouch straight in

For your refill

Aperitif Refill Pouch

Best for your second purchase onwards
60 capsules, twice the count
Same 48,000 HDUs per capsule as the jar
Slim, letterbox-friendly pouch
Pours directly into your existing jar

FAQs

Product

5 questions

How many capsules are in a jar and pouch?

A glass jar contains 30 enteric-coated capsules. A refill pouch contains 60 capsules.

What are the ingredients in Aperitif?

Aperitif is made from the highest quality ingredients, in accordance with strict EU manufacturing standards. The formulation strives for the highest level of bioavailability and absorption.

Where are the ingredients sourced?

All ingredients in Aperitif, including the gut resistant capsules, are sourced from the EU.

What about the production standards?

Aperitif is produced in accordance with European standards. The production is IFS GMP-certified (International Featured Standards for Good Manufacturing Practices).

How can I speak with a nutritional histamine expert?

The first step is to take our questionnaire. You can then find Tolerance's trusted UK nutritional histamine experts on the About Us page, and find our genetic tests on the other product page.

Usage

2 questions

Are there any side effects?

The ingredients in our supplement are generally considered safe when taken as per the directions found on the jar or refill pouch.

What is histamine intolerance?

Histamine intolerance occurs when your body can't break down histamine properly. A root cause of histamine intolerance is a deficiency or inefficiency of the enzymes that break down histamine, particularly diamine oxidase (DAO).

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Aperitif Diamine Oxidase 30 Capsule Jar