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In partnership with Lifecode Gx

Core Genetic Test

Core Genetic Test

27 genes analysed across four categories. Discover whether you have a predisposition to food sensitivities and how your body absorbs, responds and clears nutrients and toxins.

Regular price £330.00
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Holistic Genetic Assessment
Methylation, nutrition, food sensitivities, and detox in one report.
Partnered with Lifecode Gx
UK laboratory working with practitioners since 2017.
Privacy First by Design
End-to-end anonymised report readout.

Your body's whole food-response wiring, mapped.

27 genes that shape how you absorb what you eat, how you respond to it, and how you clear what your body doesn't need.

  • Methylation & nutritionHow your body activates B vitamins, folate, vitamin D, iron, and other essentials.
  • Food response & detoxificationCoeliac risk, lactose tolerance, caffeine and alcohol metabolism, and glutathione detox capacity.

What you get

  • DNA cheek swab test kit
  • Personalised Core report, colour-coded genotype results
  • Guidance for each of 27 genes across methylation, nutrition, food response, and detox
  • 30-minute nutrigenomics expert consultation

Order to result

Four steps, about four weeks

Everything happens by post and video call. Genes never change, so you only ever have to take one swab.

01

Order your kit

Letterbox friendly delivery by Royal Mail. Everything you need is in the envelope.

02

Cheek swab posted back

Rub the swab inside your cheek for one minute, sign the form, and post it back it in the pre-paid envelope.

03

The lab reads your DNA

About two weeks at Lifecode Gx's lab preparing your results.

04

Report & walkthrough

Receive your report by email, and an invitation to walk through it with a registered practitioner.

View a sample report

If you purchase the Histamine + Core bundle, you will receive both reports.

Which test is right for you?

Compare the tests

The Core test answers the wider food-response question. Histamine answers the specific one. The Bundle covers both.

Core Only Histamine Only Histamine + Core Bundle
Genes read

27 genes analysed across: food response, nutrition, methylation, detoxification.

7 genes analysed across the histamine clearance pathway.

Everything across both reports.

What you learn

Discover whether you have a predisposition to food sensitivities and how your body absorbs, responds and clears nutrients and toxins.

Where your histamine clearance may be slower and why.

Everything across both reports.

Report format

One personalised PDF, colour-coded, per-gene guidance.

One personalised PDF, colour-coded, with pathway diagram.

Two personalised reports, Histamine + Core, with pathway diagram and per-gene guidance.

Practitioner walkthrough

✓ 30 min video call

✓ 30 min video call

✓ 30 min video call

Price £330one time, forever £330one time, forever £440one time, foreverSave £220

Preview your report

What does the report tell me?

Every gene on your Core panel gets its own result card with a traffic-light indicator and plain-language explanation.

Your Results FUT2 GG

Secretor status positive. Your body produces the sugar structures that help Bifidobacteria thrive and support B12 absorption. Good gut microbiome diversity and B12 status.

LCT (MCM6) CT

Lactase persistence. Your body continues producing lactase into adulthood. Dairy tolerance is expected throughout life.

VDR AA

Effective vitamin D response. Your cells respond well to circulating vitamin D. Maintain levels with regular sun exposure.

MTHFR CT

Reduced folate activation. Your body converts dietary folate into its active form at about 65% of normal speed. Affects methylation, and downstream, histamine clearance.

CYP1A2 AC

Slower caffeine metabolism. Caffeine stays active in your system longer. It also inhibits DAO, so affects the histamine picture.

GSTM1 0/0

Detox pathway silent. This gene is entirely absent, which is common (around half the population). One of the main glutathione detox routes doesn't work.

Sample results shown for illustration only. See the sample report download above.

The full list

Every gene the Core test reads

Genes are grouped by the area they sit in. Tap a group to read what it covers and see the specific genes assessed.

Food response

Celiac disease predisposition (2 genes)

HLA variants indicate whether you carry the genetic risk for coeliac disease. A risk result is a reason to speak to your GP about a formal test, never a diagnosis on its own.
Genes read HLA-DQA1, HLA-DQB1

Lactose intolerance (1 gene)

The LCT gene controls whether your body keeps producing lactase into adulthood. Explains lifelong dairy tolerance versus later-life intolerance.
Gene read LCT

Caffeine sensitivity & metabolism (2 genes)

CYP1A2 controls how quickly caffeine is broken down. ADORA2A variants increase sensitivity to caffeine, so small amounts can have a significant stimulatory effect.
Genes read CYP1A2, ADORA2A

Microbiome diversity (1 gene)

FUT2 determines Secretor status, which shapes the balance of beneficial Bifido bacteria in your gut microbiome and influences B12 absorption.
Gene read FUT2

Nutrition

Vitamin A conversion (1 gene)

BCO1 variants reduce your ability to convert beta-carotene from plants into active vitamin A. Common — around half the population is a poor converter.
Gene read BCO1

B vitamins — absorption & use (2 genes)

FUT2 (Secretor status) and TCN2 (transcobalamin) together shape how efficiently your body absorbs and transports vitamin B12.
Genes read FUT2, TCN2

Vitamin C & collagen (2 genes)

SLC23A1 controls vitamin C transport and absorption. COL1A1 affects the composition of type-1 collagen — relevant to bone density and soft tissue integrity.
Genes read COL1A1, SLC23A1

Vitamin D response (2 genes)

GC affects how vitamin D is transported in the circulation. VDR affects how sensitively your cells respond to it once it arrives.
Genes read GC, VDR

Vitamin K recycling (1 gene)

VKORC1 enables recycling of vitamin K. Variants can disrupt blood clotting, bone density and arterial calcification.
Gene read VKORC1

Blood pressure regulation (2 genes)

ACE and AGT sit in the renin-angiotensin-aldosterone system. Variants can increase angiotensin II activity and predispose to higher blood pressure.
Genes read ACE, AGT

Appetite regulation (2 genes)

FTO shapes food preference and satiety signalling. LEPR variants reduce sensitivity to leptin, the satiety hormone, and can increase overeating risk.
Genes read FTO, LEPR

Sugar & fat metabolism (2 genes)

PGC1A regulates whole-body energy metabolism and mitochondrial function. TCF7L2 is the strongest gene link to type-2 diabetes susceptibility.
Genes read PGC1A, TCF7L2

Essential fats (2 genes)

FADS1 and FADS2 shape how effectively your body converts dietary omega-3 and omega-6 into their active forms.
Genes read FADS1, FADS2

Inflammation response (2 genes)

TNF and IFNG (interferon gamma) sit in the inflammatory response. Variants shape how strongly your body reacts to infection or ongoing irritation.
Genes read TNF, IFNG

Circadian rhythm (2 genes)

CLOCK and PER1 regulate the master body clock. Variants shape whether you tend early-bird or night-owl, and how easily you fall and stay asleep.
Genes read CLOCK, PER1

Methylation

Methylation (1 gene)

MTHFR controls the only route your body uses to convert folate into its active methyl form. Variants can slow methylation across many downstream systems — energy, mood, and histamine clearance among them.
Gene read MTHFR

Detoxification

Glutathione detoxification (1 gene)

GSTM1 uses glutathione to bind and clear toxins. A common gene deletion means many people have very low or absent GSTM1 activity — around half of Caucasians are GSTM1-null.
Gene read GSTM1

What this test can and can't tell you

A genetic test measures wiring, the fixed underlying pattern. It doesn't tell you "what's happening in my body right now".

What it can tell you

What it can't tell you

Which nutrient pathways your body naturally supports well and which it asks for more of
Your current nutrient status, which changes with diet, absorption, and season
How you tend to metabolise caffeine, alcohol, and other common substances
How much of any specific food or drink you can tolerate right now
Whether you carry the genetic markers for coeliac risk or adult lactose tolerance
Whether you currently have coeliac disease, that's a diagnosis your GP makes
How efficient your body's detox pathways are at handling everyday environmental load
Your current detox demand, which depends on lifestyle, exposure, and gut health
The wider picture of how your genetics shape absorption, response, and clearance
How you'll actually feel after any particular meal, genetics is one input among many

In partnership with

Lifecode Gx

Lifecode Gx is a specialist nutrigenomics laboratory whose reports have been trusted by healthcare practitioners since 2017. They use genomics science to enable a preventative, proactive and personalised approach to health.

Practitioner Grade Reports

Clinical grade nutrigenomics reports used by healthcare professionals across the UK.

Research Backed Approach

Lifecode Gx gene interpretation is drawn from peer-reviewed nutrigenomics research.

Complete Customer Privacy

Genetics data anonymised by barcode from the moment it arrives, and deleted six months after testing.

Lifecode Gx is an independent laboratory. Tolerance does not see customer genetics data or report results.

FAQs

Shipping

4 questions
How long does the whole process take?

Three to four weeks. The kit arrives in 1-2 days (UK) or 2-5 days (EU & US). When your cheek swab sample is returned to the lab with the pre-paid postage, lab processing takes 2-3 weeks. Your walkthrough call booking invitation follows shortly after. So, you receive the report and consultation within 3-4 weeks of your order.

Will you tell me when my sample has arrived at the lab?

No, the next you'll hear after posting your cheek swab sample is your booking invitation, about 2-3 weeks later. This is normal, your sample is not lost. You will receive some light, nutrigenomics content via email in the holding period. When your results arrive, you'll be fully up to speed.

How do I take the swab correctly?

Detailed step-by-step instructions come with your kit. If you'd like extra guidance, our written guide and short video walk through every step.

What can cause the test to fail?

It fails due to two reasons. Either the mouth swab hasn't been done properly, or the return storage instructions haven't been followed. It's important to follow all steps correctly.

Report & Walkthrough

6 questions
How does the test work?

Taking your test

Your test is a simple cheek swab. It's non-invasive, takes minutes, and can be done at any time of day.

Before you swab:

  • Don't eat, drink or smoke for at least 1 hour beforehand
  • Swab thoroughly, as insufficient DNA is the main reason samples fail lab standards

Returning your sample:

  1. Place your swab in the tube with the stabilising capsule. Include the capsule whole, don't open it
  2. Complete and sign the consent form (write Tolerance under 'practitioner')
  3. Pop both in the prepaid return envelope and drop it in any post box (UK returns are free)

No special storage or transport requirements. Return it any day.

If your sample fails: The most common causes are a missing stabilising capsule or consent form. If it does happen, you'll get one free replacement kit, re-posted at no extra charge for UK orders.

What's included in the report?

Colour coded results

Green: no variation of the gene, or the variant works in your favour
Amber: somewhat negative effect
Red: negative effect

Arrows show direction, meaning whether the variant turns that gene up or down.

What each result actually says

Not just "you have this variant" but what it does and what supports it. For example, a slower MTHFR result explains why methylation is affected, and what feeds the pathway. A GSTM1 deletion comes with the foods that support alternative glutathione routes.

What exactly does the Core Test analyse?

26 genes across nine categories.

Methylation: MTHFR, MTHFD1, FOLR1, SHMT1, DHFR, MTR, MTRR, FUT2, TCN2, PEMT, BHMT, CBS, CTH, GCH1, QDPR

Nutrition: BCO1 (vitamin A), VDR (vitamin D), HFE (iron)

Food response: HLA-DQ2 and DQ8 (coeliac risk), MCM6 (lactose), CYP1A2 (caffeine), ADH1B and ALDH2 (alcohol)

Detoxification: CYP1A1, CYP1B1, GSTM1, GSTT1

Each gene is reported with your genotype, a traffic-light indicator, and plain-language guidance for what supports the pathway.

Who will I speak to and how?

A trusted, registered practitioner who is trained on Lifecode Gx's Core reports. The video call is done through Zoom and takes thirty minutes with plenty of time for questions. If you are unable to do the preferred video call, let us know and we'll arrange an alternative method.

Can I add the Histamine test later?

Yes. If you'd like to add the Histamine test after taking the Core test, you can do so within 6 months without re-swabbing. Testing and practitioner appointments are chargeable. Drop us a message at care@gettolerance.com if you're interested.

How accurate is the genetic test?

The genotyping is at least 99.9% accurate. Anything that fails quality control is not reported. It appears as "no result" instead of a guess.

Science

6 questions
I have a cold and/or taking medication. Will my results be affected?

No. As we're testing the genetic code, which is fixed, the test is not impacted by illness, infections, medication, the food you eat or any food supplements you take. To avoid contamination of the sample, please abstain from eating / drinking for at least 1 hour before testing. Continue taking any medications and supplements as normal.

Is this a food intolerance test?

No. It does not measure your reaction to specific foods. It reads the genes that govern how your body handles them. It explains why you react rather than cataloguing what you react to. Be wary of any blood tests that claim to be food intolerance tests.

Will this diagnose coeliac disease or a food allergy?

No. What this test shows is whether you are genetically predisposed to certain conditions (like coeliac disease) or traits (like lactose tolerance). A genetic risk result is a reason to speak to your GP, never a diagnosis on its own.

What happens to my DNA and data?

All information is anonymised via barcode on arrival at the ISO-certified UK lab. Your report goes to you and to Lifecode GX's nutrigenomics expert, that's it. Your physical sample is destroyed after three months; genotyping data after six. Never sold, never shared, ever, with any third parties. You don't receive raw genome data.

Does it test for anything serious?

No. Only common variants are analysed, meaning ones present in at least 1% of the population. There are no rare disease markers and no frightening findings in the reports.

Should I get my children tested or will they have the same genes as me?

Every human has a slightly different genetic makeup. We inherit our gene variants from both parents so although you may have similar genes to your child, you won't have identical gene mutations. Our genes are the same from the moment we are born so you only ever need to do this test once in your lifetime and receive the data on your gene variants for life.

Get to know your body better than ever before.

The right information so that you can take the next best step.

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